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White (mutation)

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Title: White (mutation)  
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Subject: Sarah Elgin, Genetics, Classical genetics
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White (mutation)

A white-eyed Drosophila

White Gene, abbreviated w, was the first [2] Flies carrying the white allele/ white gene are frequently used to introduce high school and college students to genetics. The protein coded by white functions as an ATP-binding cassette (ABC) transporter. It carries the precursors of the red and brown eye color pigments, guanine and tryptophan, into the developing eyes during pupation.[3] The human version of white is ABCG1, and is involved in transporting lipids and cholesterol into cells.

Notes and references

  1. ^ Morgan, TH: (1910) "Sex Limited Inheritance in Drosophila." Science, 32(812):120-122
  2. ^ As the field of genetics developed, names for genes were italicized, and for Drosophila the normal (wild type) allele was given a + modifier, for example w+. Names of commonly used mutations were shortened, and since white was one of the first named, it was shortened to a single letter.
  3. ^ Mackenzie, S. M.; Brooker, M. R.; Gill, T. R.; Cox, G. B.; Howells, A. J.; Ewart, G. D. (1999) Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration. Biochimica et Biophysica Acta (BBA) - Biomembranes 1419: 173-185.
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