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Splenectomy

 

Splenectomy

Splenectomy
Intervention
Ruptured spleen removed by splenectomy
ICD-9-CM 41.43, 41.5
MeSH
OPS-301 code 5-413

A splenectomy is a surgical procedure that partially or completely removes the spleen.

Contents

  • Indications 1
  • Procedure 2
  • Side effects 3
  • Partial splenectomy 4
  • See also 5
  • References 6

Indications

The spleen, similar in structure to a large lymph node, acts as a blood filter. Current knowledge of its purpose includes the removal of old red blood cells and platelets, and the detection and fight against certain bacteria. It is also known to function as a site for the development of new red blood cells from their hematopoietic stem cell precursors, and particularly in situations in which the bone marrow, the normal site for this process, has been compromised by a disorder such as leukemia. The spleen is enlarged in a variety of conditions such as malaria, mononucleosis and most commonly in cancers of the lymphatics, such as lymphomas or leukemia.

It is removed under the following circumstances:

  1. When it becomes very large such that it becomes destructive to platelets/red blood cells
  2. For diagnosing certain lymphomas
  3. Certain cases of wandering spleen
  4. When platelets are destroyed in the spleen as a result of an auto-immune condition, such as idiopathic thrombocytopenic purpura.
  5. When the spleen bleeds following physical trauma
  6. Following spontaneous rupture
  7. For long-term treatment of congenital erythropoietic porphyria (CEP) if severe hemolytic anemia develops[1]
  8. The spread of gastric cancer to splenic tissue
  9. When using the splenic artery for kidney revascularisation in renovascular hypertension.
  10. For long-term treatment of congenital pyruvate kinase (PK) deficiency

The classical cause of traumatic damage to the spleen is a blow to the abdomen during a sporting event. In cases where the spleen is enlarged due to illness (mononucleosis), trivial activities, such as leaning over a counter or straining while defecating, can cause a rupture.

Procedure

accessory spleens are discovered and also removed during surgery. The incisions are closed and when indicated, a drain is left. If necessary, tissue samples are sent to a laboratory for analysis.

Side effects

As splenectomy causes an increased risk of S. pneumoniae and Haemophilus influenzae) the patient should receive the pneumococcal conjugate vaccine (Prevnar), Hib vaccine, and the meningococcal vaccine; see asplenia. These bacteria often cause a sore throat under normal circumstances but after splenectomy, when infecting bacteria cannot be adequately opsonized, the infection becomes more severe.

An increase in blood leukocytes can occur following a splenectomy.[2][3] The post-splenectomy platelet count may rise to abnormally high levels (thrombocytosis), leading to an increased risk of potentially fatal clot formation. There also is some conjecture that post-splenectomy patients may be at elevated risk of subsequently developing diabetes.[4] Splenectomy may also lead to chronic neutrophilia. Splenectomy patients typically have Howell-Jolly bodies[5][6] and less commonly Heinz bodies in their blood smears.[7] Heinz bodies are usually found in cases of G6PD (Glucose-6-Phosphate Dehydrogenase) and chronic liver disease.[8]

A splenectomy also results in a greatly diminished frequency of memory B cells.[9] A 28-year follow-up of 740 World War II veterans who had their spleens removed on the battlefield showed a significant increase in the usual death rate from pneumonia (6 rather than the expected 1.3) and an increase in the death rate from ischemic heart disease (4.1 rather than the expected 3) but not from other conditions.[10]

Partial splenectomy

Much of the spleen's protective roles can be maintained if a small amount of spleen can be left behind.[11] Where clinically appropriate, attempts are now often made to perform either surgical subtotal (partial) splenectomy,[12] or partial splenic embolization.[13] In particular, whilst vaccination and antibiotics provide good protection against the risks of asplenia, this is not always available in poorer countries.[14] However, as it may take some time for the preserved splenic tissue to provide the full protection, it has been advised that preoperative vaccination still be given.[15]

See also

References

  1. ^ Frye R. (2006-03-02). "Porphyria, Cutaneous". eMedicine. Retrieved 2006-03-28. 
  2. ^ "Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force". BMJ 312 (7028): 430–4. 1996.  
  3. ^ Davies JM, et al. (2001-06-02). "The prevention and treatment of infection in patients with an absent or dysfunctional spleen - British Committee for Standards in Haematology Guideline up-date". BMJ 320 (7028): 430–4.  
  4. ^ http://www.nytimes.com/2004/11/09/health/09diab.html?pagewanted=print&position= New York Times article
  5. ^ synd/1596 at Who Named It?
  6. ^ Katcher AL (Mar 1980). "Familial asplenia, other malformations, and sudden death". Pediatrics 65 (3): 633–5. 
  7. ^ Hematology: Clinical Principles and Applications. Rodak B, Fritsma, G and Doig, K.
  8. ^ "Anemia in Children - October 15, 2001 - American Family Physician". 
  9. ^ Kruetzmann, S; Rosado, MM; Weber, H; Germing, U; Tournilhac, O; Peter, HH; Berner, R; Peters, A; Boehm, T; Plebani, A; Quinti, I; Carsetti, R (Apr 7, 2003). "Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen". The Journal of experimental medicine 197 (7): 939–45.  
  10. ^ Dennis Robinette, C.; Fraumeni, Josephf. (1977). "Splenectomy and Subsequent Mortality in Veterans of the 1939-45 War". The Lancet 310 (8029): 127–9.  
  11. ^ Grosfeld JL, Ranochak JE (1976). "Are hemisplenectomy and/or primary splenic repair feasible?". J. Pediatr. Surg. 11 (3): 419–24.  
  12. ^ Bader-Meunier B, Gauthier F, Archambaud F, et al. (2001). "Long-term evaluation of the beneficial effect of subtotal splenectomy for management of hereditary spherocytosis". Blood 97 (2): 399–403.  
  13. ^ Pratl B, Benesch M, Lackner H, et al. (2007). "Partial splenic embolization in children with hereditary spherocytosis". Eur J Haematol 80 (1): 76–80.  
  14. ^ Sheikha AK, Salih ZT, Kasnazan KH, et al. (October 2007). "Prevention of overwhelming postsplenectomy infection in thalassemia patients by partial rather than total splenectomy". Can J Surg 50 (5): 382–6.  
  15. ^ Kimber C, Spitz L, Drake D, et al. (1998). "Elective partial splenectomy in childhood". J. Pediatr. Surg. 33 (6): 826–9.  
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