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Morazone

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Morazone

Morazone
Systematic (IUPAC) name
1,5-dimethyl-4-[(3-methyl-2-phenylmorpholin-4-yl)methyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
Clinical data
Legal status
  • Prescription only
Routes Oral, SC, IM[1]
Identifiers
CAS number  N
ATC code None
PubChem
ChemSpider  YesY
UNII  YesY
Chemical data
Formula C23H27N3O2 
Mol. mass 377.48 g/mol
 N   

Morazone (Novartrina, Orsimon, Rosimon-Neu, Tarcuzate) is a non-steroidal anti-inflammatory drug (NSAID), originally developed by the German pharmaceutical company Ravensberg in the 1950s, which is used as an analgesic.[1][2][3] It produces phenmetrazine as a major metabolite and has been reported to have been abused as a recreational drug in the past.[4][5][6][7]

See also

References

  1. ^ a b Seyffart, G. (1991). Drug dosage in Renal Insufficiency. Boston: Kluwer Academic Publishers. p. 399.  
  2. ^ US patent 2943022, Siemer, H. & Doppstadt, A., "Substituted 1-phenyl-2,3-dimethyl-4-morpholino methyl pyrazolone-(5) Compounds and Process of Making Same", issued 1960-06-28, assigned to Ravensberg 
  3. ^ J. Buckingham, ed. (1996). Dictionary of Organic Compounds 7. London: Chapman & Hall. p. 4659.  
  4. ^ Bohn, G.; Rücker, G.; Kröger, H. (1976). "Investigations of the decomposition and detection of morazone by thin-layer- and gas-liquid-chromatography". Archives of Toxicology 35 (3): 213–220.  
  5. ^ Neugebauer, M. (1984). "Some new urinary metabolites of famprofazone and morazone in man". Journal of Pharmaceutical and Biomedical Analysis 2 (1): 53–60.  
  6. ^ Kingreen, J. C.; Breger, G. (1984). "Pellagra in morazone abuse". Zeitschrift für Hautkrankheiten 59 (9): 573–577.  
  7. ^ Daunderer, M.; Janzen, W. (1972). "Rosimon-NEU--a non-prescription analgesic on the adolescent drug scene". Beiträge zur Gerichtlichen Medizin 29: 138–143.  


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