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Immunosuppression

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Title: Immunosuppression  
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Immunosuppression

Immunosuppression
Intervention
Micrograph showing an opportunistic infection due to immunosuppression - large (blue) cell below-center-left infected with a polyomavirus. Urine cytology specimen.
MeSH

Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

In general, deliberately induced immunosuppression is performed to prevent the body from graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as systemic lupus erythematosus, rheumatoid arthritis or Crohn's disease. This is typically done using medications, but may involve surgery (spleen removal), plasmapharesis, or radiation.

A person who is undergoing immunosuppression, or whose immune system is weak for other reasons (for example, chemotherapy or HIV), is said to be immunocompromised. An immunosuppressant is any agent that weakens the immune system, including immunosuppressive drugs and some environmental toxins.

Contents

  • Deliberately induced 1
  • Non-deliberate immunosuppression 2
  • See also 3
  • References 4

Deliberately induced

Administration of immunosuppressive medications or immunosuppressants is the main method of deliberately induced immunosuppression. In optimal circumstances, immunosuppressive drugs are targeted only at any hyperactive component of the immune system, and in ideal circumstances would not cause any significant immunodeficiency. However, in essence, all immunosuppressive drugs have the potential to cause immunodeficiency. Immunodeficiency may manifest as increased susceptibility to opportunistic infections and decreased cancer immunosurveillance. The term immunotoxin is also sometimes used (incorrectly) to label undesirable immunosuppressants, such as various pollutants. Immunosuppressants may be prescribed when a normal immune response is undesirable, such as in autoimmune diseases.

human leukocyte antigen haplotypes between the donor and recipient. As a result, the immune system detects the new tissue as "foreign", and attempts to remove it by attacking it with recipient white blood cells, resulting in the death of the donated tissue. Immunosuppressants are given as an attempt to prevent this rejection; the side-effect is that the body becomes more vulnerable to infections and malignancy, much like in an advanced HIV infection.

Throughout its history, radiation therapy has been used to decrease the strength of the immune system. Dr. Joseph Murray of Harvard Medical School and chief plastic surgeon at Children's Hospital Boston from 1972-1985 was awarded the Nobel Prize in Physiology or Medicine in 1990 for his work on immunosuppression.

Non-deliberate immunosuppression

Non-deliberate immunosuppression can occur in, for example, malnutrition, aging, many types of cancer (such as leukemia, lymphoma, multiple myeloma), and certain chronic infections such as Human Immunodeficiency virus (HIV).[1] The unwanted effect in non-deliberate immunosuppression is immunodeficiency that results in increased susceptibility to pathogens such as bacteria, viruses, or fungi.

Immunodeficiency is also a potential adverse effects of many immunosuppressant drugs. In this sense, the scope of the term immunosuppression in general includes both beneficial and potential adverse effects of decreasing the function of the immune system, whereas the term immunodeficiency in general refers solely to the adverse effect of increased risk for infection.

See also

References

  1. ^ Abbas, Abul K.; Lichtman, Andrew H. (29 January 2010). Basic Immunology: Functions and Disorders of the Immune System. Saunders/Elsevier.  
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